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Related Experiment Videos

Selective C7 complement deficiency causing recurrent meningococcal infection.

S J McBride1, D R McCluskey, P T Jackson

  • 1Department of Immunology, Queen's University of Belfast, UK.

The Journal of Infection
|May 1, 1991
PubMed
Summary
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Two sisters with congenital absence of the 7th complement component (C7) experienced recurrent Neisseria infections. One patient developed a rare complication of infective endocarditis caused by Neisseria meningitidis.

Area of Science:

  • Immunology
  • Genetics
  • Infectious Diseases

Background:

  • Congenital complement deficiencies are rare genetic disorders.
  • Absence of the 7th complement component (C7) leads to immunodeficiency.
  • Individuals with C7 deficiency are highly susceptible to Neisseria infections.