Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges and Barriers in Implementation of National Tuberculosis Elimination Program Guidelines at Nutrition Rehabilitation Centers in India: A Systematic Review.

Journal of epidemiology and global health·2026
Same author

Genetics-Supported Mainstream Testing Improves Access and Efficiency for Patients With Breast Cancer.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Effect of icosapent ethyl treatment on colorectal tissue marine omega-3 polyunsaturated fatty acid levels among patients with a history of adenoma: a prospective, single-arm clinical trial.

The American journal of clinical nutrition·2026
Same author

Feasibility and acceptability of an electronic decision aid for genetic testing in ovarian and pancreatic cancer patients.

Research connections·2026
Same author

AS-OCT Imaging of River Water Granuloma in a Child.

JAMA ophthalmology·2026
Same author

Case Report: Prolonged response to cabozantinib and pembrolizumab in treatment-refractory metastatic pancreatic ductal adenocarcinoma.

Frontiers in oncology·2026

Related Experiment Video

Updated: Jun 10, 2026

Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
03:32

Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment

Published on: December 27, 2024

Prophylactic total gastrectomy for individuals with germline CDH1 mutation.

Prakash K Pandalai1, Greg Y Lauwers, Daniel C Chung

  • 1Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Surgery
|August 20, 2010
PubMed
Summary

Germline CDH1 mutations significantly increase hereditary diffuse gastric cancer risk. Prophylactic total gastrectomy is recommended as serial endoscopies are insufficient for early detection.

More Related Videos

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
09:16

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

Related Experiment Videos

Last Updated: Jun 10, 2026

Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
03:32

Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment

Published on: December 27, 2024

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
09:16

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

Area of Science:

  • Oncology
  • Genetics
  • Gastroenterology

Background:

  • Germline mutations in the CDH1 gene, encoding E-cadherin, are rare but confer an 87% lifetime risk of hereditary diffuse gastric cancer.
  • Fewer than 100 prophylactic total gastrectomies have been reported for this high-risk condition.

Purpose of the Study:

  • To review outcomes of patients with germline CDH1 mutations who underwent prophylactic total gastrectomy.
  • To evaluate the efficacy of prophylactic surgery in preventing or detecting gastric cancer in high-risk individuals.

Main Methods:

  • Retrospective review of patients with germline CDH1 mutations who underwent multidisciplinary counseling and prophylactic total gastrectomy.
  • Analysis of pre- and post-operative findings, including endoscopic and pathological results, operative details, and complications.

Main Results:

  • Ten patients (median age 42) with various CDH1 mutations underwent prophylactic total gastrectomy.
  • Pathological analysis revealed noninvasive or invasive gastric cancer in 90% of patients, with only one detected pre-operatively via endoscopy.
  • The procedure had a median operative time of 213 minutes, with low rates of anastomotic leaks but some short-term and late complications.

Conclusions:

  • The majority of individuals with germline CDH1 mutations harbor occult gastric cancer foci by middle age.
  • Serial upper endoscopies are inadequate for screening in this population.
  • Prophylactic total gastrectomy is the definitive treatment of choice for managing hereditary diffuse gastric cancer risk.