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Tissue Engineering of the Intestine in a Murine Model

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

Intestinal malrotation: varied clinical presentation from infancy through adulthood.

Deepika Nehra¹, Allan M Goldstein

¹Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

|August 20, 2010

Summary

Intestinal malrotation affects all ages, with adults often presenting with abdominal pain. Delayed diagnosis is common in children and adults, highlighting the need for increased awareness and understanding of varied presentations.

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Tissue Engineering of the Intestine in a Murine Model

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Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

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Published on: February 3, 2016

Area of Science:

Gastroenterology
Pediatric Surgery
Surgical Outcomes

Background:

Intestinal malrotation is a congenital anomaly affecting the gastrointestinal tract.
While traditionally considered a condition of infancy, its presentation across all age groups is increasingly recognized.

Purpose of the Study:

To determine the incidence and clinical presentation of intestinal malrotation in infants, children, and adults.
To analyze diagnostic methods and treatment outcomes for intestinal malrotation across different age demographics.

Main Methods:

Retrospective review of 170 patients diagnosed with intestinal malrotation between 1992 and 2009.
Categorization of patients into three age groups: infants (<1 year), children (1-18 years), and adults (≥18 years).
Analysis of patient demographics, clinical history, diagnostic imaging, surgical procedures, and outcomes.

Main Results:

Adults constituted 48% of the patient cohort, often presenting with abdominal pain (87%).
Volvulus incidence decreased with age (37% in infants, 12% in adults).
Significant diagnostic delays were observed in children (59% with symptoms for years) and adults (32%), with imaging modalities varying by age group.

Conclusions:

Intestinal malrotation occurs across all age groups, with a substantial proportion presenting in adulthood.
Varied clinical presentations necessitate increased awareness to reduce diagnostic delays and improve patient outcomes.
Surgical intervention, primarily Ladd's procedure, generally leads to symptom resolution, though efficacy may slightly decrease with age.