Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells
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Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
Published on: December 20, 2014
Akiyuki Ikedo1, Ichiro Hayakawa, Takeo Usui
1Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan.
Bioorganic & Medicinal Chemistry Letters
|August 20, 2010
Abstract:
Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.
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