Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intramuscular EMG coherence in health and in neuromuscular disorders.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2010
Same author

An EMG index: Its values in health and disease and its changes with fatigue.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2010
Same author

Normative ranges by curve fitting to raw data.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·1999
Same author

Computing normative ranges without recruiting normal subjects.

Muscle & nerve·1997
Same author

Turn analysis of the EMG: the amplitude definition of a turn.

Electromyography and clinical neurophysiology·1994
Same author

Muscle fiber conduction velocity and mean power spectrum frequency in neuromuscular disorders and in fatigue.

Muscle & nerve·1992
Same journal

Corrigendum to "Kinematic effects of two therapeutic interventions for glenohumeral joint instability: A preliminary feasibility trial" [J. Electromyogr. Kinesiol. 88 (2026) 103147].

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
Same journal

Investigating the effects of conservative treatments on the flexion relaxation phenomenon for chronic low back pain: A systematic review.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
Same journal

Activation of the deep lumbar multifidus during common rehabilitation and resistance exercises.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
Same journal

Comprehensive RGBD-based shoulder kinematics using markerless anatomical landmarks detection and a 3D-printed acromial cluster during hand-cycling.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
Same journal

Variational mode decomposition based on refined composite multiscale dispersion entropy and its application in sEMG Denoising.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
Same journal

Does pain alter the spatial distribution of muscle activity in people experiencing spinal pain? A systematic review and meta-analysis.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

Innervation-zone width in disease and its changes with fatigue.

I Yaar1

  • 1Neurology Section, VA Medical Center, Providence, Rhode Island, U.S.A.

Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology
|August 20, 2010
PubMed
Summary
This summary is machine-generated.

The motor unit functional innervation zone (FINZONE) size decreases with muscle fatigue. FINZONE size also differs significantly between healthy, neuropathic, myotonic, myopathic, and myasthenic muscle groups, aiding in diagnosis.

More Related Videos

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
10:31

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Published on: September 29, 2017

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions
08:41

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions

Published on: August 14, 2021

Related Experiment Videos

Last Updated: Jun 10, 2026

Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
10:31

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Published on: September 29, 2017

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions
08:41

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions

Published on: August 14, 2021

Area of Science:

  • Neurology
  • Biomedical Engineering
  • Electromyography

Background:

  • The motor unit functional innervation zone (FINZONE) is a key electrophysiological parameter.
  • Understanding FINZONE size variations in different neuromuscular conditions is crucial for diagnosis.

Purpose of the Study:

  • To measure and compare the average FINZONE size in healthy and diseased muscles during fatigue.
  • To investigate the diagnostic potential of FINZONE size in neuromuscular disorders.

Main Methods:

  • Electromyography (EMG) interference patterns were recorded from 188 subjects using coaxial needle electrodes.
  • FINZONE size was computed during fatigue-inducing maximal voluntary contractions.
  • Subjects included healthy individuals and those with neuropathic, myasthenic, myotonic, and myopathic conditions.

Main Results:

  • FINZONE size significantly decreased with muscle fatigue across all groups (p = 0.00001).
  • Two distinct clusters emerged: myopathic/myasthenic muscles had larger FINZONE sizes, while normal/neuropathic/myotonic muscles had smaller sizes.
  • Significant decrements in FINZONE size with fatigue were observed in normal and neuropathic groups.

Conclusions:

  • FINZONE size is sensitive to muscle fatigue, showing a significant decrement.
  • Distinct FINZONE size profiles differentiate neuromuscular disease groups, suggesting diagnostic utility.
  • Further research is warranted to explore the diagnostic value and fatigue-related changes of FINZONE size.