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Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jun 10, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Oncogenes and tumor suppressor genes.

Eva Y H P Lee1, William J Muller

  • 1Department of Biological Chemistry and Department of Developmental and Cell Biology, University of California, Irvine, California 92697-4037, USA.

Cold Spring Harbor Perspectives in Biology
|August 20, 2010
PubMed
Summary

This study explores key oncogene and tumor suppressor networks in breast cancer progression, emphasizing BRCA1/2, p53, and PTEN. Targeting these pathways offers therapeutic potential for breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer progression is driven by genetic alterations activating oncogenes and inactivating tumor suppressor genes.
  • Key signaling networks involving oncogenes and tumor suppressors are crucial in breast cancer development.

Purpose of the Study:

  • To review critical oncogene and tumor suppressor signaling networks in breast cancer.
  • To highlight the roles of BRCA1/2, p53, and PTEN in breast cancer.
  • To discuss the therapeutic potential of targeting these networks.

Main Methods:

  • Review of scientific literature on breast cancer genetics and signaling pathways.
  • Emphasis on specific tumor suppressors like BRCA1/2, p53, and PTEN.
  • Discussion of mouse models for studying breast cancer initiation and progression.

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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

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Last Updated: Jun 10, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Main Results:

  • Identified key oncogene and tumor suppressor networks driving breast cancer.
  • Highlighted the importance of PTEN in regulating PI3K signaling against oncogenes like ErbB2.
  • Demonstrated the utility of mouse models in recapitulating human breast cancer genetics.

Conclusions:

  • Understanding these signaling networks is vital for breast cancer research.
  • Targeting oncogene and tumor suppressor pathways presents promising therapeutic strategies for breast cancer.
  • BRCA1/2, p53, and PTEN are critical players in breast cancer pathogenesis.