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Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
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Contrast-enhanced dedicated breast CT: initial clinical experience.

Nicolas D Prionas1, Karen K Lindfors, Shonket Ray

  • 1Department of Radiology, University of California Davis Medical Center, Sacramento, CA 95817, USA.

Radiology
|August 20, 2010
PubMed
Summary

Contrast-enhanced breast CT significantly improves the visibility of malignant breast lesions compared to unenhanced CT and mammography. Quantifying enhancement aids in breast cancer detection and diagnosis.

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Area of Science:

  • Radiology
  • Medical Imaging
  • Oncology

Background:

  • Breast cancer diagnosis relies on imaging techniques like mammography.
  • Computed tomography (CT) offers cross-sectional imaging but its role in breast lesion detection needs further evaluation.
  • Contrast material enhancement can improve lesion conspicuity in medical imaging.

Purpose of the Study:

  • To quantify contrast material enhancement in breast lesions using dedicated breast CT.
  • To compare the conspicuity of breast lesions on contrast-enhanced breast CT versus unenhanced breast CT and mammography.

Main Methods:

  • 46 women with suspicious breast lesions underwent unenhanced and contrast-enhanced breast CT.
  • Two radiologists assessed lesion conspicuity.
  • Mean lesion intensity was measured and normalized to adipose tissue.
  • Regression models analyzed factors affecting conspicuity and enhancement.

Main Results:

  • Malignant lesions were significantly more conspicuous on contrast-enhanced breast CT than unenhanced CT or mammography.
  • Malignant lesions showed greater enhancement (55.9 HU) than benign lesions (17.6 HU).
  • Ductal carcinoma in situ demonstrated significant enhancement (59.6 HU).
  • Area under the receiver operating characteristic curve for lesion enhancement was 0.876.

Conclusions:

  • Contrast-enhanced breast CT significantly improves the conspicuity of malignant breast lesions, including ductal carcinoma in situ.
  • Quantification of lesion enhancement may assist in breast cancer detection and diagnosis.