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Updated: Jun 10, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
The relationship between insulin resistance and hypercoagulability in acute ischemic stroke
Ayca Ozkul1, Eylem Telli Turgut, Ali Akyol
1Department of Neurology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey. ozkulayca@hotmail.com
European Neurology
|August 20, 2010
Summary
Insulin resistance is linked to lower levels of key anticoagulants, potentially increasing stroke severity. This suggests a procoagulant tendency in acute ischemic stroke patients with insulin resistance.
Area of Science:
- Cardiovascular Science
- Metabolic Disorders
- Neurology
Background:
- Insulin resistance impacts the coagulation system, a critical factor in acute infarcts.
- Understanding this link is crucial for managing acute ischemic stroke.
Purpose of the Study:
- To investigate the relationship between insulin resistance, hemostatic markers, and stroke severity in acute ischemic stroke patients.
Main Methods:
- Studied 75 acute ischemic stroke patients with and without insulin resistance.
- Measured levels of Protein C (PC), Protein S (PS), fibrinogen, von Willebrand factor, and antithrombin III (AT III).
- Assessed insulin resistance using the homeostasis model assessment (HOMA).
Main Results:
- Insulin-resistant patients showed significantly lower PC and PS levels.
- PC and PS levels correlated negatively with HOMA.
- Stroke severity (NIHSS score) correlated negatively with PS and AT III, but positively with fibrinogen, fasting glucose, and HOMA.
Conclusions:
- Significant associations exist between insulin resistance and hemostatic markers.
- These associations may contribute to stroke severity by promoting a procoagulant state in acute ischemic stroke.
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