Related Experiment Video

Updated: Jun 10, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Left ventricular global systolic dysfunction has a significant role in the development of diastolic heart failure in

Mihoko Kono1, Akira Kisanuki, Nami Ueya

  • 1Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|August 20, 2010
PubMed

Insights

Global systolic dysfunction significantly contributes to heart failure symptoms in patients with diastolic heart failure (DHF) and hypertension. This study clarifies the role of systolic function in DHF development.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Heart Failure Research

Background:

  • Diastolic heart failure (DHF) is often associated with regional left ventricular (LV) systolic dysfunction.
  • The precise relationship between LV systolic function and heart failure symptoms in DHF remains incompletely understood.

Purpose of the Study:

  • To investigate the association between global and regional LV systolic function and heart failure symptoms in patients with systemic hypertension and DHF.
  • To differentiate systolic function parameters in patients with DHF, asymptomatic diastolic dysfunction (ADD), and simple hypertension.

Main Methods:

  • Doppler echocardiography was used to assess LV systolic and diastolic function in 220 hypertensive patients and 30 controls.
  • Hypertensive patients were categorized into DHF, ADD, and Simple HT groups.

Main Results:

  • Patients with DHF exhibited significantly reduced ejection fraction (63±8%) compared to controls and other groups.
  • Isovolumetric contraction time was significantly prolonged in DHF patients (70±30 ms).
  • Mitral annular systolic velocities were significantly decreased in DHF and ADD groups, with further reduction in the DHF group.

Conclusions:

  • Global LV systolic dysfunction plays a significant role in the manifestation of heart failure symptoms in patients with DHF and systemic hypertension.
  • These findings highlight the importance of assessing systolic function in the management of DHF.

More Related Videos

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats07:41

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...