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Updated: Jul 22, 2026

Subtype-selective Electroporation of Cortical Interneurons
Published on: August 18, 2014
Intragenic sequences affect the expression of the gene encoding glial fibrillary acidic protein
1Department of Biochemistry, New York University Medical Center, New York 10016.
Abstract:
We show that the expression of the gene encoding glial fibrillary acidic protein (GFAP) gene is affected by at least three cis-acting elements. A positive regulatory element that is located between nucleotides -1,631 and -1,479 can confer cell type-specific expression on a heterologous gene. A second regulatory element is located between nucleotides -97 and -80. The third is a negative regulatory element that is located within the first intron of the gene. Deletion of this element activates GFAP expression in HeLa cells, and affects promoter function in glioma cells.
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