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Updated: Jun 10, 2026

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
Published on: June 30, 2016
Optical path clearing and enhanced transmission through colloidal suspensions
J Baumgartl1, T Cizmár, M Mazilu
1School of Physics and Astronomy, University of St. Andrews, North Haugh, St Andrews KY16 9SS, UK. jb211@st-andrews.ac.uk
Abstract:
We utilize advanced laser fields to clear a path through a dynamic turbid medium, a concept termed "Optical path clearing (OPC)." Particles are evacuated from a volume of the medium using the gradient and/or scattering forces due to an applied laser field with a suitably tailored spatial profile. Our studies encompass both an analytical model and proof-of-principle experiments where paths are cleared in dense bulk colloidal suspensions. Based on our results we suggest that high-performance and high efficiency OPC will be achieved by multiple-step clearing using dynamic laser fields based on Airy or inverted axicon beams.
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