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Related Experiment Video

Updated: Jun 10, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Rikkunshito and ghrelin.

Tomohisa Hattori¹

¹Tsumura & Co., Tsumura Research Laboratories, 3586 Yoshiwara, Ami-machi Inashiki-gun, 300-1192 Ibaraki, Japan.

International Journal of Peptides

|August 20, 2010

Summary

Rikkunshito, a Japanese herbal medicine, effectively treats gastrointestinal issues like dyspepsia and chemotherapy-induced anorexia by increasing ghrelin levels. This traditional medicine offers a new strategy for improving upper gastrointestinal dysfunction.

Area of Science:

Gastroenterology
Pharmacology
Traditional Japanese Medicine

Background:

Rikkunshito is a widely prescribed Japanese herbal medicine for gastrointestinal disorders.
Studies indicate rikkunshito improves gastric emptying and protects gastric mucosa.
It shows efficacy in managing chemotherapy-induced anorexia and vomiting.

Purpose of the Study:

To investigate the mechanism of rikkunshito in alleviating gastrointestinal disorders, particularly those induced by anticancer agents.
To explore rikkunshito's role in treating anorexia and upper gastrointestinal dysfunction.

Main Methods:

Clinical studies and animal models were used to assess rikkunshito's effects.
Investigated rikkunshito's impact on gastric emptying, mucosal injury, and symptoms like nausea and anorexia.

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Last Updated: Jun 10, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

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Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells

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Published on: April 20, 2017

Examined the role of circulating ghrelin concentration in rikkunshito's therapeutic effects.

Main Results:

Rikkunshito significantly improved dysmotility-like dyspepsia and upper gastric symptoms in a double-blind study.
Animal studies demonstrated enhanced gastric emptying and mucosal protection with rikkunshito.
Rikkunshito ameliorated cisplatin-induced anorexia by increasing ghrelin levels and reversed SSRI-induced decreased gut contractions via ghrelin.

Conclusions:

Rikkunshito effectively alleviates various gastrointestinal disorders, including chemotherapy-induced anorexia and dyspepsia.
The mechanism involves enhancing circulating ghrelin concentration, which impacts gastric motility.
Rikkunshito presents a promising therapeutic strategy for anorexia and upper gastrointestinal dysfunction.