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Ghrelin in chronic kidney disease.
1Division of Pediatric Nephrology, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, Mail code no. 0634, La Jolla, CA 92093-0634, USA.
International Journal of Peptides
|August 20, 2010
Summary
Ghrelin, a gastric hormone, may treat anorexia and inflammation in chronic kidney disease (CKD) patients. This review explores ghrelin
Area of Science:
- Nephrology
- Endocrinology
- Gastroenterology
Background:
- Chronic kidney disease (CKD) is linked to anorexia, cachexia, and inflammation.
- These conditions decrease patient quality of life and increase mortality.
- Chronic inflammation is implicated in CKD complications like renal osteodystrophy and cardiovascular risk.
Purpose of the Study:
- To review the potential of ghrelin as a treatment for anorexia in CKD patients.
- To discuss the anti-inflammatory properties of ghrelin and their relevance to CKD.
- To explore the metabolic effects and implications of ghrelin in the context of CKD.
Main Methods:
- Literature review of studies on ghrelin, its receptor (GHSR), and their effects.
- Analysis of ghrelin's impact on appetite, inflammation, and metabolism in CKD models and patients.
- Discussion of current evidence, limitations, and future research directions for ghrelin therapy in CKD.
Main Results:
- Ghrelin stimulates appetite and meal appreciation, suggesting therapeutic potential for CKD-related anorexia.
- Ghrelin exhibits anti-inflammatory properties, which could mitigate CKD-associated inflammation.
- Ghrelin's metabolic effects are being investigated for their implications in managing CKD complications.
Conclusions:
- Ghrelin holds promise as a treatment for anorexia and inflammation in CKD.
- Further research is needed to fully understand ghrelin's efficacy, safety, and optimal use in CKD patients.
- Addressing the strengths, shortcomings, and unanswered questions is crucial for advancing ghrelin-based therapies in CKD.
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