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PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP
Published on: April 9, 2013
Outpatient parenteral antimicrobial therapy: Recent developments and future prospects.
M Estee Török1, Ann L N Chapman, M P Albert Lessing
1Cambridge University Hospitals NHS Foundation Trust, Department of Infectious Diseases, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK. estee.torok@addenbrookes.nhs.uk
Current Opinion in Investigational Drugs (London, England : 2000)
|August 20, 2010
Summary
Outpatient parenteral antimicrobial therapy (OPAT) offers a safe and effective alternative to hospitalization for serious infections. Advances in antimicrobial agents are expanding treatment options and improving patient convenience and cost-effectiveness.
Area of Science:
- Infectious Diseases
- Pharmacology
- Antimicrobial Stewardship
Background:
- Parenteral antimicrobial therapy for serious infections typically requires hospitalization.
- Outpatient Parenteral Antimicrobial Therapy (OPAT) has emerged as a viable alternative globally over the past 30 years.
- OPAT offers potential benefits in safety, efficacy, patient convenience, and cost-effectiveness.
Purpose of the Study:
- To review recent developments in antimicrobial agents used for OPAT.
- To explore future prospects for antimicrobial agents in the OPAT setting.
- To highlight the expanding scope of infections treatable with OPAT.
Main Methods:
- Review of current literature on antimicrobial agents used in OPAT.
- Analysis of established and emerging antimicrobial drugs for outpatient use.
- Discussion of new developments including broader-spectrum agents and antifungals.
Main Results:
- A variety of infections are amenable to OPAT.
- Established agents like ceftriaxone and teicoplanin, and newer agents like ertapenem and daptomycin are utilized.
- Newer agents with broader activity against resistant organisms and antifungal agents are increasingly used in OPAT.
Conclusions:
- OPAT is a well-established and expanding treatment modality.
- Ongoing development of antimicrobial agents promises to further enhance OPAT efficacy and applicability.
- Future OPAT treatments will likely incorporate novel agents like telavancin, dalbavancin, and omadacycline.
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