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Relation of MT1-MMP gene expression to outcomes in colorectal cancer
Amane Kanazawa1, Takashi Oshima, Kazue Yoshihara
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Kanagawa-ken, Japan. amanex2009@gmail.com
Background:
Matrix metalloproteinases are members of a large family of endopeptidases that participate in the extracellular-matrix degradation that accompanies cancer cell invasion, metastasis and angiogenesis. The membrane-type 1 matrix metalloproteinase (MT1-MMP) gene has been reported in various cancers and is associated with tumor invasion and metastasis. This study examined the relation of the relative expression of MT1-MMP gene to clinicopathological factors and outcomes in patients with colorectal cancer (CRC).
Methods:
We studied surgical specimens of cancer tissue and adjacent normal mucosa obtained from 202 patients with untreated CRC. The relative expression levels of MT1-MMP mRNA in cancer and in normal adjacent mucosa were measured by quantitative real-time reverse-transcriptase polymerase chain reaction.
Results:
MT1-MMP gene expression was higher in cancer tissue than in adjacent normal mucosa. The level of MT1-MMP gene expression was not related to any clinicopathological factor. Overall survival at 5 years differed significantly between patients with high MT1-MMP gene expression and those with low expression.
Conclusions:
Overexpression of the MT1-MMP gene is considered a useful independent predictor of outcomes in patients with CRC.