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Related Concept Videos

Introduction to Metabolism01:30

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
What is Metabolism?00:52

What is Metabolism?

Overview
Overview of Metabolism01:40

Overview of Metabolism

Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Respiration Pathways01:26

Respiration Pathways

Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
The Citric Acid Cycle02:36

The Citric Acid Cycle

The citric acid cycle, also known as the Krebs cycle or TCA cycle, consists of several energy-generating reactions that yield one ATP molecule, three NADH molecules, one FADH2 molecule, and two CO2 molecules.
The Citric Acid Cycle: Output01:28

The Citric Acid Cycle: Output

The citric acid cycle is termed an amphibolic pathway as it operates both anabolically and catabolically. The cyclic reactions balance the flux of the substrates to provide an optimal concentration of NADH and ATP to the cell.
Regulation of Citric Acid Cycle
The citric acid cycle is regulated in several ways, including feedback inhibition, regulation of enzyme activities, and associated anaplerotic or cataplerotic pathways.
The primary substrate of the TCA cycle—acetyl CoA—is produced by the...

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Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping
09:20

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Published on: March 23, 2022

Cycling through metabolism.

Victor Aguilar1, Lluis Fajas

  • 1IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM, U896, Université de Montpellier1, CRLC Val d'Aurelle Paul Lamarque, Montpellier, France.

EMBO Molecular Medicine
|August 20, 2010
PubMed
Summary
This summary is machine-generated.

Cell cycle regulators like cyclins are increasingly linked to cellular metabolism. Recent mouse studies highlight their role in metabolic control, relevant to obesity and diabetes.

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Area of Science:

  • Cell Biology
  • Metabolic Regulation
  • Molecular Oncology

Background:

  • Cell proliferation is tightly regulated by cell cycle regulators.
  • Cellular metabolism must adapt to support proliferation.
  • The interplay between cell cycle control and metabolism is an emerging research area.

Purpose of the Study:

  • To review recent findings on cell cycle regulators' impact on cellular metabolism.
  • To highlight studies using mouse models to investigate this relationship.
  • To discuss the implications for metabolic disorders like obesity and diabetes.

Main Methods:

  • Literature review focusing on recent data.
  • Analysis of studies employing mouse models.
  • Synthesis of findings related to cell cycle regulators and metabolic control.

Main Results:

  • Cell cycle regulators, including cyclins, cyclin-dependent kinases, and E2F transcription factor, influence metabolic pathways.
  • Mouse models provide crucial insights into the in vivo mechanisms linking cell cycle and metabolism.
  • Evidence suggests a direct impact of cell cycle machinery on metabolic adaptation.

Conclusions:

  • Cell cycle regulators play a significant role in metabolic control.
  • Understanding this link is crucial for addressing metabolic diseases.
  • Further research in mouse models can elucidate therapeutic strategies for obesity and diabetes.