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A new direct pancreatic function test in pediatrics.

J A Madrazo-de la Garza1, M Gotthold, R B Lu

  • 1Department of Pediatrics, Hahnemann University, Philadelphia, Pennsylvania 19101-1192.

Journal of Pediatric Gastroenterology and Nutrition
|April 1, 1991
PubMed
Summary
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A new endoscopic method simplifies duodenal fluid collection for exocrine pancreatic function tests. This faster, reliable technique aids in diagnosing pancreatic issues in young children.

Area of Science:

  • Pediatric Gastroenterology
  • Diagnostic Procedures
  • Pancreatic Exocrine Function

Background:

  • Traditional duodenal fluid collection methods are lengthy and complex.
  • Accurate exocrine pancreatic function tests are crucial for pediatric gastrointestinal health.

Purpose of the Study:

  • To introduce and evaluate a simplified endoscopic technique for duodenal fluid collection.
  • To assess the efficacy of this method for exocrine pancreatic function testing in children.

Main Methods:

  • Compared a novel endoscopic aspiration method with a traditional tube method in 35 pediatric patients (24-36 months).
  • Patients presented with chronic diarrhea or failure to thrive.
  • Duodenal fluid was collected after secretin (SEC) administration, with some receiving pancreozymin (PZN) as well.

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Main Results:

  • The endoscopic method (group 2) took 45 minutes, significantly faster than the 3-hour traditional method (group 1).
  • SEC administration yielded comparable enzyme levels in both groups.
  • PZN administration showed the highest enzyme levels, particularly for lipase, though not always significantly higher than SEC alone.

Conclusions:

  • Endoscopic duodenal fluid collection after SEC administration is a safe, rapid, and dependable approach.
  • This technique offers a significant improvement for performing exocrine pancreatic function tests in young children.