Jove
Visualize
Contact Us

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin.

Nature·2025
Same author

Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin.

Nature·2025
Same author

The origin of synthons and supramolecular motifs: beyond atoms and functional groups.

IUCrJ·2025
Same author

Identification of Ni<sup>2+</sup>-binding peptides in sunflower meal protein hydrolysate for deeper understanding of peptide-metal interactions.

Journal of inorganic biochemistry·2025
Same author

Combining Desferriferrioxamine B and 1-Hydroxy-2-Piperidone ((PIPO)H) to Chelate Zirconium. Solution Structure of a Model Complex of the [<sup>89</sup>Zr]Zr-DFOcyclo*-mAb Radioimmunoconjugate.

ChemPlusChem·2024
Same author

Screening, separation and identification of metal-chelating peptides for nutritional, cosmetics and pharmaceutical applications.

Food & function·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 10, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Nickel(II)-dipeptidoamine-based tetrameric complex: structural study in solution and in solid state.

Katalin Selmeczi1, Patrick Gizzi, Delphine Champmartin

  • 1Laboratoire SRSMC (UMR 7565 CNRS-Université Henri Poincaré Nancy 1), BP 70239, F-54506 Vandoeuvre-lès-Nancy Cedex, France. katalin.selmeczi@srsmc.uhp-nancy.fr

Inorganic Chemistry
|August 21, 2010
PubMed
Summary

This study details the synthesis and crystal structure of a neutral tetranuclear nickel(II) complex, revealing a saddle-like coordination environment. Spectroscopic and computational analyses confirm its tetranuclear structure in solution, differing from the solid state.

More Related Videos

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry
16:11

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry

Published on: June 8, 2022

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

Related Experiment Videos

Last Updated: Jun 10, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry
16:11

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry

Published on: June 8, 2022

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

Area of Science:

  • Coordination chemistry
  • Supramolecular chemistry
  • Bioinorganic chemistry

Background:

  • Previous studies predicted M(4)L(4)H(-8) macromolecular structures using spectroscopic and potentiometric data.
  • Peptidic ligands (Xaa-His or Xaa-His-Yaa) are known to form coordination complexes with various metal ions.

Purpose of the Study:

  • To synthesize and determine the crystal structure of a neutral tetranuclear nickel(II) complex (1) with α-methyl-alanyl-histamine ligands.
  • To investigate the complexation of Ni(II) with the ligand using potentiometric and spectrophotometric methods.
  • To elucidate the solution structure and compare it with the solid-state structure using NMR and DFT calculations.

Main Methods:

  • X-ray crystallography for solid-state structure determination.
  • Potentiometric titration and UV-visible spectrophotometry for complexation studies.
  • Proton and Carbon-13 Nuclear Magnetic Resonance (NMR) spectroscopy for solution structure analysis.
  • Density Functional Theory (DFT) calculations for structural optimization.
  • Electrospray Ionization High-Resolution Mass Spectrometry (ESI-HRMS) for nuclearity confirmation.

Main Results:

  • The crystal structure of the neutral tetranuclear nickel(II) complex 1 (C(36)H(56)N(16)Ni(4)O(4)·4.5CH(3)OH·1.5H(2)O) was determined, exhibiting a square planar geometry around each Ni(II) ion.
  • The four NiLH(-2) units form a C(1) symmetrical saddle-like macromolecule.
  • Complexation studies indicated the predominant species at pH 8.0 is M(4)L(4)H(-8) with an oligomerization pK(4) of 5.73.
  • Solution NMR suggested an S(4) symmetry, contrasting with the C(1) solid-state symmetry, which was further investigated by DFT calculations.
  • ESI-HRMS confirmed the tetranuclear nature of the complex in solution.

Conclusions:

  • A novel neutral tetranuclear nickel(II) complex with a unique saddle-like structure was successfully synthesized and characterized.
  • The study highlights the differences between solid-state and solution structures of coordination macromolecules.
  • The findings contribute to understanding the structural diversity and behavior of metal-peptidic complexes.