An occult cause of hemodialysis vascular access dysfunction
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Updated: Jun 10, 2026

A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
Pei-Ching Kuo1, Chih-Cheng Wu, Wen-Jone Chen
1Department of Medicine, Hsinchu General Hospital, Hsinchu, Taiwan.
Insights
Vascular access dysfunction in hemodialysis patients can stem from hidden subclavian artery stenosis. Early detection of inflow problems is crucial for effective treatment and improved patient outcomes.
Area of Science:
- Nephrology
- Vascular Surgery
- Interventional Radiology
Background:
- Vascular access dysfunction is a common complication in hemodialysis patients.
- Venous stenosis is a frequent cause, but stenosis can occur throughout the access circuit.
Observation:
- A 75-year-old female patient experienced recurrent hemodialysis access issues requiring multiple angioplasties.
- Diagnostic evaluation revealed a previously unrecognized stenosis in the subclavian artery.
Findings:
- Subclavian artery stenosis, often atherosclerotic, can be a challenging cause of hemodialysis vascular access dysfunction.
- Delayed diagnosis is common due to complexities in vascular access management.
Implications:
- This case underscores the importance of considering inflow stenosis remote from the anastomosis.
- Identifying key indicators for early detection of inflow problems can improve patient care.
- Physicians must maintain a high index of suspicion for atypical stenosis locations.
Abstract:
Although hemodialysis vascular access dysfunction is often caused by venous stenosis, stenosis can occur anywhere in the circuit. Herein, we report a 75-year-old woman who received repeated percutaneous angioplasty due to insufficient flow. Finally, a culprit stenosis at the subclavian artery was found and treated. Subclavian artery stenosis is often atherosclerotic in origin and is usually delayed to be diagnosed because of caveats in the care of vascular access. This case highlights important clues that can assist in the early discovery of inflow problems and reminds the physician that inflow stenosis may be hidden at a site far from the anastomosis.
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