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Brain immunohistopathological study in a patient with anti-NMDAR encephalitis
J-P Camdessanché1, N Streichenberger, G Cavillon
1Service de Neurologie, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.
Background And Purpose:
Anti-N-methyl-D-asparate (NMDA) receptor encephalitis is thought to be antibody-mediated. To perform an immunohistopathological study of the inflammatory reaction in a brain biopsy performed before immunomodulatory treatments in a patient with anti-NMDA receptor encephalitis.
Methods:
An immunohistochemical study was performed using CD3, CD68, CD20, CD138 and CD1a antibodies.
Results:
Prominent B-cell cuffing was present around brain vessels accompanied by some plasma cells, while macrophages and T cells were scattered throughout the brain parenchyma.
Conclusion:
These findings suggest that the B cells interact with the T cells and are involved in antibody secretion by the plasma cells.
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