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Related Experiment Video

Updated: Jun 10, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

Endothelial nitric oxide synthase polymorphisms and erectile dysfunction: a meta-analysis.

Jia-Li Wang¹, Hai-Gang Wang, Hai-Qing Gao

¹Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.

The Journal of Sexual Medicine

|August 21, 2010

Summary

This summary is machine-generated.

The endothelial nitric oxide synthase G894T variant is linked to an increased risk of erectile dysfunction (ED). However, no significant association was found between the 4 VNTR polymorphism and ED susceptibility.

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En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

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Published on: February 25, 2016

Area of Science:

Genetics
Molecular Biology
Urology

Background:

Erectile dysfunction (ED) significantly impacts quality of life.
Endothelial nitric oxide synthase (eNOS) gene polymorphisms are investigated for their role in ED susceptibility.
Previous studies on eNOS polymorphisms and ED risk have yielded conflicting results due to low statistical power.

Purpose of the Study:

To conduct a meta-analysis to estimate the association between eNOS variants and the risk of ED.
To consolidate evidence from existing studies to provide a more robust assessment of the eNOS-ED relationship.

Main Methods:

A systematic search of Medline and Embase databases was performed for studies on eNOS polymorphisms and ED.
Nine eligible articles were included in the meta-analysis.
Five genetic models and a generalized odds ratio (OR(G)) were used to analyze the association between eNOS G894T and 4 VNTR polymorphisms and ED risk.

Main Results:

The eNOS G894T variant showed a significant association with increased ED risk across most genetic models (allele contrast OR = 1.64, 95% CI: 1.03-2.60).
The meta-analysis using OR(G) also indicated a significant association (OR(G) = 1.64, 95% CI: 1.03-2.61).
No significant association was observed between the eNOS 4 VNTR polymorphism and ED risk (OR = 0.96, 95% CI: 0.72-1.28).

Conclusions:

The G894T variant of eNOS is associated with an increased risk of erectile dysfunction.
No significant association was found between the 4 VNTR polymorphism and ED.
Results should be interpreted cautiously, and further large-scale, well-designed studies are recommended for confirmation.