Related Experiment Video

Updated: Jun 10, 2026

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
08:28

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Published on: March 10, 2020

Evaluation of growth and neurodevelopment in children with congenital heart disease

Selda Polat1, Cetin Okuyaz, Olgu Hallioğlu

  • 1Department of Pediatrics, Mersin University Faculty of Medicine, Mersin, Turkey. seldapolat2003@hotmail.com

Pediatrics International : Official Journal of the Japan Pediatric Society
|August 21, 2010
PubMed

Insights

Children with congenital heart disease (CHD) face risks in growth and development. Impaired hemodynamic status significantly impacts physical growth and neurodevelopment, highlighting the need for detailed assessments beyond routine parameters.

Area of Science:

  • Pediatrics
  • Cardiology
  • Developmental Pediatrics

Background:

  • Children with congenital heart disease (CHD) are at increased risk for delayed growth and neurodevelopmental outcomes.
  • Hemodynamic status is a critical factor influencing these outcomes in pediatric patients with CHD.

Purpose of the Study:

  • To evaluate physical growth parameters and neurodevelopment in children with CHD.
  • To compare these parameters with healthy children.
  • To examine the specific effect of hemodynamic status on growth and development in children with CHD.

Main Methods:

  • A comparative study included 76 children with CHD and 51 healthy controls, aged 1-72 months.
  • Children with CHD were categorized into hemodynamically impaired (HI) and hemodynamically normal (HN) groups.
  • Growth parameters (weight, height, BMI, MAC, TSF) and neurodevelopment (Denver Developmental Screening Test-II) were assessed.

Main Results:

  • Hemodynamically impaired children with CHD showed significantly lower mid-arm circumference (MAC) and body mass index (BMI) compared to HN and control groups.
  • The HI group exhibited more failures in gross motor, fine motor, and language development compared to HN and control groups.

Conclusions:

  • Hemodynamic status is crucial for the growth and neurodevelopment of children with CHD.
  • Detailed assessments including BMI, MAC, TSF, and developmental screening tests are vital for identifying at-risk children with CHD.
Abstract

More Related Videos

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Pulse rhythm01:30

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Mitral Stenosis IV: Nursing Management01:27

Mitral Stenosis IV: Nursing Management

A comprehensive nursing assessment is essential for patients with valvular heart disease, which involves any dysfunction of the heart valves that could impact blood flow and overall heart function.Subjective Data Collection:Chief Complaint and Present Illness: Start with the patient's primary concerns, focusing on the onset, duration, and progression of cardiac symptoms such as dyspnea, fatigue, chest pain, and palpitations.Past Medical History: Collect detailed information on any previous...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...