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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Antimicrobial susceptibility of Staphylococcus aureus in children with atopic dermatitis

Ching-Shen Tang1, Chih-Chien Wang, Ching-Feng Huang

  • 1Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|August 21, 2010
PubMed

Insights

Staphylococcus aureus (S. aureus) nasal carriage and skin infections in children with atopic dermatitis (AD) are common. High rates of methicillin-resistant S. aureus (MRSA) and multi-drug resistance necessitate careful antibiotic selection for effective treatment.

Area of Science:

  • Pediatric Dermatology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Atopic dermatitis (AD) in children increases risk for Staphylococcus aureus (S. aureus) skin infections and nasal carriage.
  • S. aureus colonization and infection can exacerbate AD and lead to recurrent infections.

Purpose of the Study:

  • To evaluate antibiotic susceptibilities of S. aureus strains in children with AD.
  • To determine optimal antibiotic choices for treating S. aureus in this population.

Main Methods:

  • Nasal swabs collected from 168 healthy children with AD and 20 AD children with skin and soft-tissue infections (SSTI).
  • S. aureus strains analyzed for antibiotic susceptibilities and prevalence of methicillin-resistant S. aureus (MRSA).

Main Results:

  • High prevalence of S. aureus colonization (46.4%) and MRSA (30.8%) in healthy AD children.
  • MRSA identified in 60% of SSTI-causing strains.
  • High resistance rates to erythromycin; all strains susceptible to vancomycin, rifampin, and mupirocin.
  • Multi-drug resistance observed in 70% of colonizing and 50% of SSTI strains; inducible clindamycin resistance common.

Conclusions:

  • S. aureus strains from children with AD exhibit significant MRSA and multi-drug resistance.
  • Trimethoprim-sulfamethoxazole, rifampin, fusidic acid, and mupirocin are recommended for S. aureus treatment and decolonization in AD patients.
Abstract

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