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Novel hypertrophic cardiomyopathy phenotype: segmental hypertrophy isolated to the posterobasal left ventricular free

Barry J Maron1, Mark V Sherrid, Tammy S Haas

  • 1Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minnesota, USA. hcm.maron@mhif.org

The American Journal of Cardiology
|August 21, 2010
PubMed

Insights

This study highlights the diverse presentations of hypertrophic cardiomyopathy (HC). Novel cases with posterobasal left ventricular (LV) hypertrophy and mitral valve prolapse further expand the known morphologic spectrum of this disease.

Area of Science:

  • Cardiology
  • Genetics
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HC) is known for its wide range of clinical presentations.
  • Understanding this phenotypic heterogeneity is crucial for accurate diagnosis and management.

Observation:

  • Two new patients presented with isolated posterobasal left ventricular (LV) free wall hypertrophy.
  • Both patients also exhibited mitral valve prolapse.

Findings:

  • These cases add to the known morphologic diversity of hypertrophic cardiomyopathy.
  • The findings underscore the continued evolution of understanding HC phenotypes, even with advanced imaging.

Implications:

  • These observations expand the recognized spectrum of hypertrophic cardiomyopathy.
  • Further research into the genetic and molecular underpinnings of these diverse phenotypes is warranted.
  • Improved characterization of HC variants may lead to more personalized treatment strategies.

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