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Updated: Jun 10, 2026

Quantification of Endothelial Fatty Acid Uptake using Fluorescent Fatty Acid Analogs
Published on: August 15, 2025
Fatty acid-binding protein 4 is associated with endothelial dysfunction in patients with type 2 diabetes
Gemma Aragonès1, Raimon Ferré, Iolanda Lázaro
1Research Unit on Lipids and Atherosclerosis, Universitat Rovira i Virgili, Internal Medicine Department, Sant Joan University Hospital, IISPV, CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Reus, Spain.
Objective:
Adipocyte fatty acid-binding protein (FABP4) plasma levels are higher in type 2 diabetes (T2D). Endothelial dysfunction is also common in T2D. We have investigated the relationship between circulating FABP4 levels and endothelial function in diabetic patients.
Methods:
In 257 patients (105 diabetic and 152 non-diabetic) at increased risk of cardiovascular disease, we measured circulating FABP4, reactive hyperemia index (RHI) by peripheral artery tonometry, intima-media thickness, and biomarkers of inflammation, oxidation and endothelial function.
Results:
In T2D subjects, FABP4 was negatively associated with endothelial function, as measured by RHI (r=-0.226, P=0.05). In a stepwise multivariate linear regression model, FABP4 was a predictor of RHI in T2D patients (P=0.04).
Conclusion:
Circulating levels of FABP4 are inversely associated with endothelial function in T2D patients, as measured by RHI. We suggest a direct effect of plasma FABP4 on the vascular endothelium in those with T2D.
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