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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontitis affects neurological deficit in acute stroke.
Joanna Slowik1, Marcin A Wnuk, Kinga Grzech
1Jagiellonian University Medical College, Institute of Dentistry, Krakow, Poland.
Journal of the Neurological Sciences
|August 21, 2010
Summary
Advanced periodontitis or toothlessness in stroke patients is linked to more severe neurological deficits upon admission. This condition independently predicts greater initial stroke severity, though it doesn't impact long-term outcomes.
Area of Science:
- Neurology
- Periodontology
- Public Health
Background:
- Periodontitis is a known risk factor for ischemic stroke.
- The impact of severe periodontitis or edentulousness on stroke severity remains under-investigated.
Purpose of the Study:
- To investigate the association between advanced periodontitis/edentulousness and neurological deficit on admission.
- To assess the relationship between advanced periodontitis/edentulousness and short-term stroke outcomes.
Main Methods:
- 169 ischemic stroke patients were analyzed.
- Neurological deficit was measured using the NIH Stroke Scale (NIHSS).
- Clinical attachment level (CAL) ≥6mm defined advanced periodontitis.
Main Results:
- Patients with advanced periodontitis/edentulousness were older and had higher NIHSS scores on admission.
- Advanced periodontitis or edentulousness was an independent predictor of greater NIHSS on admission.
- Stroke severity on admission, not periodontitis, influenced patient outcomes.
Conclusions:
- Advanced periodontitis or edentulousness is associated with increased neurological deficit upon admission in ischemic stroke patients.
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