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Iminoheterocycles as gamma-secretase modulators

John P Caldwell1, Chad E Bennett, Troy M McCracken

  • 1Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States. john.caldwell@merck.com

Bioorganic & Medicinal Chemistry Letters
|August 21, 2010
PubMed
Summary

Researchers developed new iminoheterocycles to modulate gamma-secretase activity. These compounds show potent gamma-secretase modulation, good pharmacokinetics, and reduce Abeta42 levels in vivo.

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