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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
[Postirradiation angiosarcoma of the breast]
Gergely Vertse1, Egon Svastics, András Iványi
1Fovárosi Onkormányzat Károlyi Sándor Kórház és Rendelointézet Altalános Sebészeti Osztály 1041 Budapest Nyár u. 103. vertseg@freemail.hu
Magyar Sebeszet
|August 21, 2010
Summary
Secondary angiosarcomas (AS) are rare but aggressive breast cancers that can develop years after breast conserving therapy (BCT) and radiotherapy. Early diagnosis and radical surgery are crucial for successful treatment of this aggressive neoplasm.
Area of Science:
- Oncology
- Surgical Pathology
- Radiotherapy Research
Background:
- Secondary angiosarcomas (AS) are rare but aggressive neoplasms.
- Increasing recognition links AS to breast conserving therapy (BCT) followed by radiotherapy.
- Diagnosis relies on immunohistochemical analysis of biopsy specimens.
Observation:
- A 56-year-old woman underwent BCT and radiotherapy for breast cancer.
- Ten years post-treatment, secondary AS developed in the remaining breast tissue.
- The tumor exhibited aggressive and rapid spread characteristics.
Findings:
- Immunohistochemistry is key for diagnosing secondary angiosarcomas.
- Radical surgical intervention remains the primary curative treatment.
- AS can manifest a decade after initial breast cancer treatment.
Implications:
- Highlights the importance of long-term surveillance for patients treated with BCT and radiotherapy.
- Underscores the aggressive nature of secondary angiosarcomas, necessitating prompt diagnosis and treatment.
- Suggests further research into the mechanisms linking radiotherapy to AS development.
