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Transcellular transactivation by the human immunodeficiency virus type 1 tat protein
D E Helland1, J L Welles, A Caputo
1Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
Journal of Virology
|August 1, 1991
Abstract:
The human immunodeficiency virus type 1 (HIV-1) transactivator (tat) protein produced in one cell activated HIV-1 promoter-directed gene expression in a second cell, provided the cells were in direct contact with one another. This observation suggests that the tat protein produced in HIV-1-infected cells has a physiological effect on neighboring cells.