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Updated: Jun 10, 2026

Studying Organelle Dynamics in B Cells During Immune Synapse Formation
15:39

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Published on: June 1, 2019

Complement-dependent transport of antigen into B cell follicles

Santiago F Gonzalez1, Veronika Lukacs-Kornek, Michael P Kuligowski

  • 1The Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital, Boston, MA 02115, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|August 21, 2010
PubMed

Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.

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