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Updated: Jun 10, 2026

Time-Lapse Video Microscopy for Assessment of EYFP-Parkin Aggregation as a Marker for Cellular Mitophagy
Published on: May 4, 2016
Uncovering the roles of PINK1 and parkin in mitophagy
Noriyuki Matsuda1, Keiji Tanaka
1Protein metabolism project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan. matsuda-nr@igakuken.or.jp
Abstract:
Parkinson disease (PD) is the second most prevalent neurodegenerative disorder, and thus elucidation of the pathogenic mechanism and establishment of a fundamental cure is essential in terms of public welfare. Fortunately, our understanding of the pathogenesis of two types of recessive familial PDs--early-onset familial PD caused by dysfunction of the PTEN induced putative kinase 1 (PINK1) gene and autosomal recessive juvenile Parkinsonism (ARJP) caused by a mutation in the Parkin gene--has evolved and continues to expand.
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