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Updated: Jun 10, 2026

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

Published on: February 15, 2019

Corneal morphogenesis during development and diseases.

Winston W-Y Kao¹

¹Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267-0838, USA. winston.kao@uc.edu

Eye & Contact Lens

|August 21, 2010

Summary

This summary is machine-generated.

Genetically modified mouse models reveal how genetic mutations cause corneal defects. These models, using doxycycline-inducible systems, allow precise control over gene expression to study developmental processes and diseases.

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Area of Science:

Ophthalmology
Developmental Biology
Genetics

Background:

Corneal morphogenesis is a complex process crucial for vision.
Understanding genetic mutations underlying corneal diseases is essential for developing effective treatments.

Purpose of the Study:

To review the utility of genetically modified mouse lines in studying corneal development and disease.
To highlight the application of doxycycline-inducible systems for precise genetic manipulation in corneal research.

Main Methods:

Development of doxycycline-inducible (tet-On) mouse models using transgenesis and gene targeting.
Creation of driver lines (Krt12-rtTA, Kera-rtTA) for specific gene expression in corneal cells.
Generation of bitransgenic and triple transgenic mice to study gene function and ablation.

Main Results:

Overexpression of FGF7 in corneal epithelial cells induced beta-catenin nuclear translocation and hyperplasia, mimicking ocular surface squamous neoplasia.
Constitutive nuclear translocation of mutant beta-catenin in corneal epithelial cells led to hyperproliferation.
Expression of mutant beta-catenin in periocular mesenchymal cells resulted in eyelid malformation.

Conclusions:

Genetically modified mice are invaluable tools for investigating the pathophysiology of ocular surface defects.
These models facilitate the study of genetic mutations impacting corneal development and disease progression.