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Hormone replacement therapy and the adolescent.

Amy D Divasta1, Catherine M Gordon

  • 1Children's Hospital Boston, Division of Adolescent Medicine, 333 Longwood Avenue, Boston, MA 02115, USA. amy.divasta@childrens.harvard.edu

Current Opinion in Obstetrics & Gynecology
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PubMed
Summary
This summary is machine-generated.

Hormonal replacement therapy (HRT) is crucial for adolescents with pubertal hormone deficiencies. Current data are limited, necessitating a stepwise approach and further research for optimal treatment strategies.

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Area of Science:

  • Endocrinology
  • Pediatric Endocrinology
  • Adolescent Medicine

Background:

  • Adolescents and young women often require hormonal replacement therapy (HRT) due to deficiencies in pubertal hormones.
  • Hypogonadism is a common endpoint for various conditions necessitating HRT in this demographic.

Purpose of the Study:

  • To provide an update on hormonal replacement therapy (HRT) for adolescents and young women with pubertal hormone deficiencies.
  • To review current issues and evidence to aid clinicians in managing these patients.

Main Methods:

  • Review of recent evidence regarding transdermal versus oral preparations for HRT.
  • Examination of the effects of HRT on skeletal health.
  • Discussion of newer methods for administering HRT.

Main Results:

  • Optimal HRT regimens for adolescents remain unclear, with limited specific data available.
  • A stepwise approach to HRT, involving gradual dose increases, is suggested.
  • Evidence on different preparation routes, skeletal effects, and novel delivery methods is presented.

Conclusions:

  • HRT is essential for many adolescents with hypogonadism, yet evidence-based guidelines are lacking.
  • Prospective data are limited, hindering evidence-based decision-making for optimal treatment.
  • Establishment of research consortia is recommended to investigate optimal HRT regimens and improve clinical care.