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Overcoming the Barrier Treatment of Ichthyosis: A Combination-therapy Approach

Susun Bellew1, James Q Del Rosso

  • 1Valley Hospital Medical Center, Las Vegas, Nevada.

The Journal of Clinical and Aesthetic Dermatology
|August 21, 2010
PubMed

Ichthyosis vulgaris is an inherited disorder of keratinization that results in asteatotic scales on extensor surfaces of the arm, legs, and trunk. A combination-therapy approach with a physiological lipid-based barrier repair topical emulsion and ammonium lactate 12% lotion applied topically was shown to be effective at four-week follow up without any untoward side effects. This combination therapy addresses the importance of caring for both the corneocytes ("bricks") and the intercellular lipid bilayer ("mortar") for optimal benefit.

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