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Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

A mathematical model for DNA damage and repair.

Philip S Crooke1, Fritz F Parl

  • 1Department of Mathematics, Vanderbilt University, Nashville, TN 37240, USA.

Journal of Nucleic Acids
|August 21, 2010
PubMed
Summary

This study models DNA damage and repair, focusing on estrogen-induced DNA adducts and base excision repair (BER). The findings reveal how imbalances impact genome integrity, offering insights into mutagenesis and carcinogenesis.

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