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Published on: April 12, 2018
Artificial, switchable K+-gated ion channels based on flow-through titania-nanotube arrays
Bin Zhu1, Jingjian Li, Qingwei Chen
1State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing, PR China.
Abstract:
In the present work, we demonstrated a novel type of artificial K(+)-gated ion channels based on titania nanotubes loaded with Au nanoparticles and G-rich DNA composite structure. K(+) promoted conformational change of G-rich DNA from flexible chain to rigid quadruplex, which provided a blocking effect for the transport of anions such as Fe(CN)(6)(4-) and other molecules through the channels in TiO(2) nanotubes. This fabricated permselective membrane using K(+) as a trigger may set light to the field of biosensing, drug-release, ion exchange membrane and so on.
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