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[Increased corneocyte surface area in the diabetic skin]
Y Yajima1, H Sueki, R Fujisawa
1Department of Dermatology, Showa University School of Medicine.
Nihon Hifuka Gakkai Zasshi. the Japanese Journal of Dermatology
|February 1, 1991
Summary
Diabetic patients have larger corneocyte surface areas compared to non-diabetics, suggesting a delayed skin turnover time in diabetics. This finding highlights potential differences in skin physiology.
Area of Science:
- Dermatology
- Diabetology
- Cell Biology
Context:
- Diabetes mellitus is associated with various microvascular and macrovascular complications.
- Alterations in skin structure and function are observed in diabetic individuals.
- Corneocyte size and density are indicators of epidermal turnover and barrier function.
Purpose:
- To investigate the hypothesis that corneocyte surface area is larger in diabetic patients compared to age-matched non-diabetic controls.
- To analyze the correlation between corneocyte surface area, age, and diabetes status.
- To assess potential differences in the number of corneocytes collected between the two groups.
Summary:
- Corneocyte surface area was measured in 50 diabetics and 43 non-diabetics.
- Diabetic corneocyte surface area was consistently larger across all age groups, with significant differences in the 4th, 7th, and 8th decades.
- A significant correlation between corneocyte surface area and age was observed in non-diabetics, but not in diabetics.
Impact:
- The findings suggest that the turnover time of the stratum corneum may be delayed in diabetic patients.
- This could have implications for understanding diabetic skin complications and wound healing.
- Further research into the mechanisms underlying altered corneocyte dynamics in diabetes is warranted.