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Symptom cluster and physical activity in relapsing-remitting multiple sclerosis.

Robert W Motl1, Madeline Weikert, Yoojin Suh

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A three-symptom cluster of fatigue, depression, and pain moderately predicts physical activity in relapsing-remitting multiple sclerosis (RRMS). This finding holds even after accounting for exercise history and neurological impairment.

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Area of Science:

  • Neurology
  • Rehabilitation Science
  • Behavioral Medicine

Background:

  • Relapsing-remitting multiple sclerosis (RRMS) significantly impacts patients' quality of life and physical function.
  • Understanding factors influencing physical activity is crucial for managing RRMS.
  • Symptom clusters may offer a consolidated view of disease burden and its impact on behavior.

Purpose of the Study:

  • To compare the explanatory power of two symptom clusters on physical activity in RRMS patients.
  • To identify the most relevant symptoms correlating with reduced physical activity in RRMS.

Main Methods:

  • Covariance modeling was used for data analysis in a cohort of 218 individuals with RRMS.
  • Two symptom clusters were evaluated: one with three symptoms (fatigue, depression, pain) and another with five symptoms (including cognitive dysfunction and sleep quality).

Main Results:

  • A three-symptom cluster (fatigue, depression, pain) showed a moderate, negative association with physical activity.
  • This association was similar in magnitude to a five-symptom cluster.
  • The relationship between symptom clusters and physical activity was reduced after controlling for exercise history and neurological impairment.

Conclusions:

  • A concise cluster of three symptoms (fatigue, depression, pain) independently correlates with physical activity in RRMS.
  • This highlights the importance of these specific symptoms in understanding physical activity limitations in RRMS.
  • Future interventions could target these core symptoms to improve physical activity levels.