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Related Experiment Video

Updated: Jun 10, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
12:19

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Soft tissue adaptation to modified titanium surfaces.

Shermin Lee1, Bee Tin Goh, Joop Wolke

  • 1Department of Oral and Maxillofacial Surgery, National Dental Centre, Singapore. shermin@rocketmail.com

Journal of Biomedical Materials Research. Part A
|August 21, 2010
PubMed
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Hydroxyapatite/bioglass coatings improved soft tissue adaptation in mucosal tissues, unlike dual acid-etched Osseotite® surfaces which showed no benefit for muscle tissue adherence in titanium implants.

Area of Science:

  • Biomaterials Science
  • Implantology
  • Tissue Engineering

Background:

  • Minimizing soft tissue dehiscence around implants is crucial.
  • Surface modification of titanium alloys aims to enhance soft tissue integration.

Purpose of the Study:

  • To evaluate the efficacy of dual acid-etched Osseotite® surfaces for muscle tissue adherence.
  • To assess the potential of radio frequency magnetron sputtered hydroxyapatite (HA)/bioglass (BG) coatings for mucosal tissue adherence.

Main Methods:

  • Comparison of Osseotite® and HA/BG coated Ti6Al4V implants against machined controls in Macaca fascicularis.
  • Intramuscular insertion of Osseotite® coated bullets and submucosal insertion of HA/BG coated plates.
  • Histological and histomorphometrical analysis of tissue response and interface quality.

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Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
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Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Related Experiment Videos

Last Updated: Jun 10, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
12:19

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Main Results:

  • No significant difference in muscle tissue response between machined and Osseotite® surfaces.
  • HA/BG coated submucosal plates demonstrated significantly thinner capsule quantity (p < 0.0001) and improved capsule and interface quality (p < 0.0001, p < 0.05).

Conclusions:

  • Hydroxyapatite/bioglass coatings significantly enhance soft tissue adaptation in mucosal tissues.
  • Osseotite® surface modification did not improve muscular adaptation for titanium implants.