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Related Experiment Video

Updated: Jun 10, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

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Published on: September 1, 2011

Hyperprolactinaemia induced by proton pump inhibitor.

Abdul Jabbar¹, Rabbia Khan, Syed Nadir Farrukh

¹Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.

JPMA. the Journal of the Pakistan Medical Association

|August 24, 2010

Summary

Omeprazole, a common proton pump inhibitor, can cause hyperprolactinemia and galactorrhea. This case highlights a rare side effect in a 13-year-old girl.

Area of Science:

Endocrinology
Pharmacology

Background:

Proton pump inhibitors (PPIs) are widely prescribed for acid-related gastrointestinal disorders.
Hyperprolactinemia, elevated prolactin levels, can lead to various symptoms, including galactorrhea.

Observation:

A 13-year-old female presented with symptoms suggestive of hyperprolactinemia.
The patient was concurrently using Omeprazole, a common PPI, for an unspecified condition.

Findings:

The patient exhibited hyperprolactinemia and galactorrhea.
These symptoms were determined to be induced by Omeprazole therapy.

Implications:

This case underscores a potential, albeit rare, adverse drug reaction associated with Omeprazole.
Clinicians should consider drug-induced hyperprolactinemia in patients presenting with relevant symptoms, especially those on PPIs.

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