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Updated: Jun 10, 2026
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
[Effects of alcohol on acute myocardial ischemia induced by pituitrin in rats]
Huikang He1, Mengjie Tang, Xinghui Wang
1College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
Objective:
To observe the effects of alcohol intake at different levels on acute myocardial ischemia induced by pituitrin in rats.
Methods:
Forty SD male rats were randomly divided into five groups, including model control group (pituitrin, 1U/kg), positive control group (verapamil, 1 mg/kg), 5% alcohol group (0.4 g/kg), 10% alcohol group (0.8 g/kg) and 20% alcohol group (1.6 g/kg). Myocardial ischemia model was made in rats by injecting pituitrin (1U/kg) through sublingual vein. The heart rate, incidence of arrhythmia, the changes of ST segment and T wave on electrocardiogram of rats were observed and compared.
Results:
The incidence of arrhythmia, the degree of elevated ST segment and T wave amplitude induced by pituitrin were remitted obviously in the 5% alcohol group (0.4 g/kg); The heart rate was slower and the change of ST segment and T wave were not affected in the 10% alcohol group (0.8 g/kg). The heart rate was slower and the elevated ST segment and the T wave amplitude were augmented significantly in the 20% alcohol group (1.6 g/kg).
Conclusion:
A protective effect on acute myocardial ischemia induced by pituitrin in rats was shown in the 5% alcohol group (0.4 g/kg) and an aggravation of acute myocardial ischemia induced by pituitrin was observed in the 20% alcohol group (1.6 g/kg).