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[Study on safety and immunogenicity of oral poliomyelitis attenuated live vaccine (human diploid cell)]

Shao-Hong Guo1, Hong Tao, Zhi-fang Ying

  • 1Beijing Tiantan Biological Products Co., Ltd., Beijing 100024, China.

Zhongguo Yi Miao He Mian Yi
|August 24, 2010
PubMed

Insights

The Poliomyelitis vaccine (Human Diploid Cell) is safe and effective for children aged 2 months and older. This study demonstrates high immune response rates, confirming its immunogenicity in young children.

Area of Science:

  • Vaccinology
  • Immunology
  • Pediatrics

Context:

  • Poliomyelitis remains a global health concern, necessitating effective vaccination strategies.
  • The human diploid cell (HDC) origin poliomyelitis vaccine (OPV) offers a potential alternative for polio prevention.
  • Evaluating vaccine safety and immunogenicity in target populations is crucial for public health.

Purpose:

  • To assess the safety and immunogenicity of the poliomyelitis vaccine (Human Diploid Cell) in children aged two months and older.
  • To determine the immune response and identify any adverse events associated with the OPV (HDC) vaccine.

Summary:

  • A randomized, blind, and controlled trial involving 1200 healthy children (2-5 months old) in Jiangsu province evaluated the OPV (HDC) vaccine against control vaccines.
  • Following three doses, the OPV (HDC) vaccine demonstrated mild systemic reactions.
  • Immune success rates for poliovirus types I, II, and III were high (98.28%, 99.45%, 95.71%), with significant geometric mean titers (GMTs) observed in susceptible children.

Impact:

  • The findings support the safety and immunogenicity of the OPV (HDC) vaccine for infants and young children.
  • This vaccine represents a potentially valuable tool in global poliomyelitis eradication efforts.
  • The study provides robust data for public health policy regarding polio vaccination.
Abstract

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