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Bioprospecting of Extremophilic Microorganisms to Address Environmental Pollution
Published on: December 30, 2021
Microbial transformation of albendazole
G Shyam Prasad1, S Girisham, S M Reddy
1Department of Microbiology, Kakatiya University, Warangal 506 009, India. shyamprasad1919@yahoo.com
Indian Journal of Experimental Biology
|August 24, 2010
Summary
Microorganisms can transform the anthelmintic drug albendazole into active metabolites. This study identified bacterial and actinomycetes strains capable of biotransforming albendazole, demonstrating microbial versatility for chemical synthesis.
Area of Science:
- Microbiology
- Biotechnology
- Drug Metabolism
Background:
- Albendazole is a key anthelmintic drug.
- Biotransformation by microorganisms offers sustainable synthesis routes.
- Understanding microbial metabolism of albendazole is crucial for drug development.
Purpose of the Study:
- To screen bacterial and actinomycetes strains for albendazole biotransformation.
- To identify microbial metabolites of albendazole.
- To assess the potential of microbial biotransformation for producing active albendazole metabolites.
Main Methods:
- Screening of twelve bacterial strains and five actinomycetes cultures.
- High-Performance Liquid Chromatography (HPLC) for transformation identification.
- Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS-MS) for metabolite structure elucidation.
Main Results:
- Several microbial strains demonstrated albendazole biotransformation capabilities.
- Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae produced one metabolite.
- Enterobacter aerogenes, Klebsiella aerogenes, Pseudomonas aeruginosa, and Streptomyces griseus produced two metabolites, identified as albendazole sulfoxide (M1) and albendazole sulfone (M2).
Conclusions:
- Microbial biotransformation is a viable method for producing albendazole metabolites.
- Albendazole sulfoxide (M1), the active metabolite, can be generated using microbial processes.
- This highlights the potential of microorganisms in industrially relevant chemical synthesis.
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