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Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
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Published on: September 26, 2016

Flow-induced polymer translocation through narrow and patterned channels.

Arash Nikoubashman1, Christos N Likos

  • 1Institute of Theoretical Physics, Heinrich Heine University of Dusseldorf, Universitatsstrasse 1, D-40225 Dusseldorf, Germany. arash.nikoubashman@uni-duesseldorf.de

The Journal of Chemical Physics
|August 24, 2010
PubMed
Summary
This summary is machine-generated.

Dendrimers translocate through pores independently of size above a critical flow, unlike linear polymers. Attractive channel walls significantly alter polymer translocation dynamics, with dendrimers docking and walking, while linear chains spread out.

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Area of Science:

  • Polymer physics
  • Nanotechnology
  • Biophysics

Background:

  • Understanding polymer translocation through confined geometries is crucial for nanotechnology and drug delivery.
  • Polymers driven by solvent flow in channels present unique transport phenomena.

Purpose of the Study:

  • To investigate the translocation dynamics of linear and branched polymers (dendrimers) through narrow and patterned channels.
  • To determine the influence of channel geometry and wall interactions on polymer transport.

Main Methods:

  • Theoretical analysis using scaling arguments.
  • Computer simulations to model polymer behavior in channels.

Main Results:

  • Dendrimer translocation probability is independent of monomer number and requires a critical solvent flow.
  • On smooth channels, linear and branched polymers exhibit similar translocation times.
  • Attractive wall patches cause dendrimers to 'walk' along the channel, while linear polymers spread out.

Conclusions:

  • Channel wall properties, particularly attractive patches, critically influence polymer translocation mechanisms.
  • Dendrimers show distinct translocation behavior compared to linear polymers in patterned channels.
  • Findings have implications for drug delivery using dendritic molecules in microfluidic systems.