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Clinical significance of Staphylococcus lugdunensis isolated from routine cultures

Elizabeth Kleiner1, Alastair B Monk, Gordon L Archer

  • 1Department of Medicine, Division of Infectious Diseases, Virginia Commonwealth University Medical Center, Medical College of Virginia Campus, Richmond, Virginia, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|August 24, 2010
PubMed

Insights

Staphylococcus lugdunensis is a significant pathogen, frequently causing skin infections in healthy outpatients. This study analyzed 42 clinical isolates, confirming its clinical relevance.

Area of Science:

  • Microbiology
  • Clinical Infectious Diseases

Background:

  • Staphylococcus lugdunensis is a coagulase-negative staphylococcus species.
  • It is increasingly recognized as a pathogen, distinct from Staphylococcus aureus.

Purpose of the Study:

  • To characterize the clinical significance and sources of Staphylococcus lugdunensis isolates.
  • To evaluate the prevalence of Staphylococcus lugdunensis in clinical specimens.

Main Methods:

  • Isolates were identified using phenotypic and genotypic methods.
  • Clinical data and specimen sources were reviewed retrospectively.

Main Results:

  • 42 Staphylococcus lugdunensis isolates were recovered over one year.
  • 36 (86%) isolates were deemed clinically significant pathogens.
  • The majority of significant isolates (83%) were associated with skin and soft-tissue infections, often from healthy outpatients.

Conclusions:

  • Staphylococcus lugdunensis is a clinically important pathogen.
  • Skin and soft-tissue infections are common manifestations.
  • The organism frequently causes infections in otherwise healthy individuals.

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