Related Experiment Video
Updated: Jun 10, 2026
12:13
Ex Situ Normothermic Machine Perfusion of Donor Livers
Published on: May 26, 2015
Survival after transfusion in the Netherlands
B A Borkent-Raven1, M P Janssen, C L van der Poel
1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Vox Sanguinis
|August 24, 2010
Summary
Blood transfusion recipients have higher mortality rates than the general population, but this difference decreases over time. Survival rates vary by blood component type, with red blood cell transfusions showing higher survival than fresh frozen plasma or platelet transfusions.
Area of Science:
- Hematology
- Public Health
- Medical Statistics
Background:
- Accurate life expectancy estimates post-transfusion are crucial for cost-effectiveness analyses of blood safety.
- Survival data, stratified by age and blood component, are essential for these estimates.
Purpose of the Study:
- To determine survival rates and life expectancy following blood product transfusions.
- To compare mortality rates of transfusion recipients with the general population.
Main Methods:
- The PROTON study collected transfusion data from 1996-2006 in the Netherlands.
- PROTON data were matched with national mortality records for survival analysis.
- Survival rates were calculated per blood component type and age group, and compared to general population mortality.
Main Results:
- 92% of 2,405,012 transfusions were successfully matched to mortality data.
- One-year survival rates were 65.4% (RBC), 70.4% (FFP), and 53.9% (PLT).
- Five-year survival rates were 46.6% (RBC), 58.8% (FFP), and 39.3% (PLT).
- Ten-year mortality remained elevated compared to the general population.
Conclusions:
- Transfusion recipients exhibit higher mortality than the general population, with diminishing excess risk over time.
- Mortality rates in the Netherlands were found to be lower than in comparable international studies.
More Related Videos
Related Concept Videos
02:45Blood Transfusion and Agglutination
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:15Blood Transfusion
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...