Related Experiment Video
Updated: Jun 10, 2026
08:31
Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
Published on: September 12, 2025
Therapeutic concepts in mantle cell lymphoma
Jose Rodriguez1, Antonio Gutierrez, Antonia Obrador-Hevia
1Department of Internal Medicine, University Hospital Severo Ochoa, Leganes, Madrid, Spain. joseguez89@hotmail.com
European Journal of Haematology
|August 24, 2010
Summary
Mantle cell lymphoma treatment is evolving from palliative chemotherapy to potentially curative chemoimmunotherapy and stem cell transplantation. New targeted drugs and personalized approaches are emerging to address the disease's molecular basis.
Area of Science:
- Oncology
- Hematology
Background:
- Mantle cell lymphoma (MCL) has historically been considered incurable with standard chemotherapy.
- Recent advances show potential for cure with intensive chemoimmunotherapy and stem cell transplantation.
Purpose of the Study:
- To review current therapeutic strategies for MCL.
- To discuss emerging drugs targeting molecular alterations in MCL.
- To explore future individualized treatment approaches for MCL.
Main Methods:
- Review of current literature on MCL treatment.
- Analysis of recent clinical trial data.
- Discussion of novel targeted therapies and biomarkers.
Main Results:
- Intensive chemoimmunotherapy and stem cell transplantation offer potential cures for MCL.
- Allogeneic stem cell transplantation shows promise in relapsed/refractory cases.
- New drugs targeting specific molecular pathways are becoming available.
Conclusions:
- MCL treatment is shifting towards potentially curative strategies.
- Understanding MCL's biology is crucial for developing targeted therapies.
- Future treatment will likely involve individualized approaches based on risk factors and molecular biomarkers.
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
01:27Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...