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Related Concept Videos

Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
What is the Immune System?01:38

What is the Immune System?

Overview
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

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Related Experiment Video

Updated: Jun 10, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

Curating the innate immunity interactome.

David J Lynn1, Calvin Chan, Misbah Naseer

  • 1Animal & Bioscience Research Department, AGRIC, Teagasc, Grange, Dunsany, Co. Meath, Ireland. david.lynn@teagasc.ie

BMC Systems Biology
|August 24, 2010
PubMed
Summary
This summary is machine-generated.

The InnateDB database manually curates the human and mouse innate immunity interactome, enhancing systems-level analysis. This curated data aids in identifying novel regulators and understanding cross-talk with other biological processes.

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Last Updated: Jun 10, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

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Published on: March 2, 2014

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Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
07:36

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection

Published on: February 28, 2021

Area of Science:

  • Immunology
  • Systems Biology
  • Bioinformatics

Background:

  • Innate immunity relies on complex signaling and transcriptional networks.
  • Systems biology offers new insights into innate immunity regulation.
  • Contextual cataloging of molecular interactions is crucial for systems-level analysis.

Purpose of the Study:

  • To describe the InnateDB curation project for the innate immunity interactome.
  • To present a novel software system for accurate and standards-compliant curation.
  • To demonstrate how curated data enhances systems-level analysis of innate immunity.

Main Methods:

  • Manual annotation of human and mouse innate immunity interactome data.
  • Development of a novel curation software system for accuracy and compliance.
  • Curation of over 13,000 interactions (protein, DNA, RNA) from biomedical literature.

Main Results:

  • InnateDB curation significantly enhances network and pathway annotation for systems-level analysis.
  • Analysis of the innate immunity interactome can identify novel signaling, transcriptional, and post-transcriptional regulators.
  • Insights into cross-talk between innate immunity and other processes like adaptive immunity, cancer, and diabetes were revealed.

Conclusions:

  • Manual curation of the InnateDB interactome provides extensive data for systems-level analysis of innate immunity.
  • The curated interactome facilitates the discovery of novel regulatory mechanisms in innate immunity.
  • InnateDB aids in understanding the complex interplay between innate immunity and other biological systems.