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Updated: Jun 10, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Atherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE-/-/LDL-/- double knockout mice

Alexander C Langheinrich1, Marian Kampschulte, Franziska Scheiter

  • 1Department of Radiology, Justus-Liebig University Giessen, Giessen, Germany. alexander.langheinrich@radiol.med.uni-giessen.de

BMC Nephrology
|August 24, 2010
PubMed
Abstract

Insights

Atherosclerosis in apoE-/-/LDL-/- mice kidneys leads to reduced vascular volume and altered glomeruli. This mouse model shows significant kidney changes, mirroring human disease progression.

Area of Science:

  • Cardiovascular Research
  • Nephrology
  • Medical Imaging

Background:

  • ApoE-/-/LDL-/- double knockout mice serve as a model for human atherosclerosis.
  • The study investigates potential kidney alterations linked to renal artery atherosclerosis in these mice.

Purpose of the Study:

  • To examine kidney structural and vascular changes in aged apoE-/-/LDL-/- double knockout mice.
  • To correlate renal artery atherosclerosis with intra-renal vascular alterations and glomerular pathology.

Main Methods:

  • Micro-CT and Nano-CT imaging of kidneys from aged apoE-/-/LDL-/- and control mice.
  • Histological analysis of glomeruli and immunohistochemistry for vascular markers.
  • Quantification of renal vascular volume and glomerular morphology.

Main Results:

  • Significant reduction in renal total vascular volume fraction in knockout mice.
  • Presence of advanced atherosclerotic lesions and neovascularization in renal arteries.
  • Increased glomerular size and number, with 41% showing lipoprotein-associated glomerulopathy (LPG) and capillary aneurysms.

Conclusions:

  • Reduced intra-renal vascular volume is associated with systemic atherosclerosis in this model.
  • Kidney alterations, including glomerular changes and LPG, are evident in apoE-/-/LDL-/- mice with renal artery atherosclerosis.

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