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Updated: Jun 10, 2026
Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 17, 2011
BRCA1: linking HOX to breast cancer suppression
Kideok Jin1, Saraswati Sukumar
1Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns, Hopkins, Johns Hopkins University School of Medicine, 1650 Orleans Street, Room 143 CRB1, Baltimore, MD 21231, USA.
Abstract:
Homeobox (HOX) genes play key roles in embryogenesis and tissue differentiation. Recently, a number of groups have reported altered HOX gene expression in breast cancer. However, the mechanism of HOX gene regulation and the search for direct targets of its transcriptional regulatory function have been minimally fruitful. Recently, Gilbert and colleagues reported that HOXA9 restrains breast cancer progression by upregulation of BRCA1, a tumor suppressor. This finding raises our hope that more, rather elusive targets of HOX genes important in tumor progression or suppression will be found in the future.
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